The Calculation of the 97.5% Upper Confidence Bound: Application to Clustered Binary Data in a Binomial Non-Inferiority Two-Sample Trial.
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Abstract:
This paper will discuss the analysis of a cluster randomized binomial non-inferiority two-sample trial. The determination of the intra-cluster correlation coefficient (ICC) and its use in the calculation of the 97.5% upper confidence bound for delta, the true difference in binomial proportions between the active control and the experimental treatment groups, will be outlined.
Subject Area:
Clinical Trials
Suggested Citation:
William F. McCarthy, "The Calculation of the 97.5% Upper Confidence Bound: Application to Clustered Binary Data in a Binomial Non-Inferiority Two-Sample Trial." (July 2008). COBRA Preprint Series. Article 37.
http://biostats.bepress.com/cobra/ps/art37