Biostatistics creates and applies methods for quantitative research in the health sciences. Our faculty conduct research across the spectrum of statistical science from foundations of inference to the discovery of new methodology to health applications. Our designs and analytic methods enable health scientists and professionals in academia, government, pharmaceutical companies, medical research organizations and elsewhere to efficiently acquire knowledge and draw valid conclusions from their ever-expanding sources of information.

A collection of working papers and related research documents from the department faculty may be found here.

Further information about the department may be found at www.biostat.jhsph.edu.

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Papers from 2004

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Clustering and Classification Methods for Gene Expression Data Analysis, Elizabeth Garrett-Mayer and Giovanni Parmigiani

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Cross-study Validation and Combined Analysis of Gene Expression Microarray Data, Elizabeth Garrett-Mayer, Giovanni Parmigiani, Xiaogang Zhong, Leslie Cope, and Edward Gabrielson

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Semiparametric Regression in Capture-Recapture Modelling, O. Gimenez, C. Barbraud, Ciprian M. Crainiceanu, S. Jenouvrier, and B.T. Morgan

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ON MARGINALIZED MULTILEVEL MODELS AND THEIR COMPUTATION, Michael E. Griswold and Scott L. Zeger

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Bayesian Hierarchical Distributed Lag Models for Summer Ozone Exposure and Cardio-Respiratory Mortality, Yi Huang, Francesca Dominici, and Michelle L. Bell

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Multiple Lab Comparison of Microarray Platforms, Rafael A. Irizarry et al.

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Choosing Smoothness Parameters for Smoothing Splines by Minimizing and Estimate of Risk, Rafael A. Irizarry

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Inequity Measures for Evaluations of Environmental Justice: A Case Study of Close Proximity to Highways in NYC, Jerry O. Jacobson, Nicolas W. Hengartner, and Thomas A. Louis

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Effect of Misreported Family History on Mendelian Mutation Prediction Models, Hormuzd A. Katki

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Ranking USRDS Provider-Specific SMRs from 1998-2001, Rongheng Lin, Thomas A. Louis, Susan M. Paddock, and Greg Ridgeway

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Screening for Differentially Expressed Genes: Are Multilevel Models Helpful?, Dongmei Liu, Giovanni Parmigiani, and Brian Caffo

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Optimal Sample Size for Multiple Testing: the Case of Gene Expression Microarrays, Peter Muller, Giovanni Parmigiani, Christian Robert, and Judith Rousseau

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Seasonal Analyses of Air Pollution and Mortality in 100 U.S. Cities, Roger D. Peng, Francesca Dominici, Roberto Pastor-Barriuso, Scott L. Zeger, and Jonathan M. Samet

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The National Morbidity, Mortality, and Air Pollution Study Database in R, Roger D. Peng, Leah J. Welty, and Aidan McDermott

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A Hierarchical Multivariate Two-Part Model for Profiling Providers' Effects on Healthcare Charges, John W. Robinson, Scott L. Zeger, and Christopher B. Forrest

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Studying Effects of Primary Care Physicians and Patients on the Trade-Off Between Charges for Primary Care and Specialty Care Using a Hierarchical Multivariate Two-Part Model, John W. Robinson, Scott L. Zeger, and Christopher B. Forrest

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Self-Reported Memory Symptoms with Coronary Artery Disease: A Prospective of CABG Patients and Nonsurgical Controls, Ola A. Selnes; Maura A. Grega; Louis M. Borowicz, Jr.; Sarah Barry; Scott L. Zeger; and Guy M. McKhann

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Squared Extrapolation Methods (SQUAREM): A New Class of Simple and Efficient Numerical Schemes for Accelerating the Convergence of the EM Algorithm, Ravi Varadhan and Ch. Roland

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A Model Based Background Adjustment for Oligonucleotide Expression Arrays, Zhijin Wu, Rafael A. Irizarry, Robert Gentleman, Francisco Martinez Murillo, and Forrest Spencer

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A Cox Model for Biostatistics of the Future, Scott L. Zeger, Peter J. Diggle, and Kung-Yee Liang

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On Time Series Analysis of Public Health and Biomedical Data, Scott L. Zeger, Rafael A. Irizarry, and Roger D. Peng

Papers from 2003

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Time-Series Studies of Particulate Matter, Michelle L. Bell, Jonathan M. Samet, and Francesca Dominici

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Modeling the Incubation Period of Anthrax, Ron Brookmeyer, Elizabeth Johnson, and Sarah Barry

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Unification of Variance Components and Haseman-Elston Regression for Quantitative Trait Linkage Analysis, Wei-Min Chen, Karl W. Broman, and Kung-Yee Liang

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Kernel Estimation of Rate Function for Recurrent Event Data, Chin-Tsang Chiang, Mei-Cheng Wang, and Chiung-Yu Huang

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Underestimation of Standard Errors in Multi-Site Time Series Studies, Michael Daniels, Francesca Dominici, and Scott L. Zeger

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Smooth Quantile Ratio Estimation, Francesca Dominici, Leslie Cope, Daniel Q. Naiman, and Scott L. Zeger

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Hierarchical Bivariate Time Series Models: A Combined Analysis of the Effects of Particulate Matter on Morbidity and Mortality, Francesca Dominici, Antonella Zanobetti, Scott L. Zeger, Joel Schwartz, and Jonathan M. Samet

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Smooth Quantile Ratio Estimation with Regression: Estimating Medical Expenditures for Smoking Attributable Diseases, Francesca Dominici and Scott L. Zeger

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Checking Assumptions in Latent Class Regression Models via a Markov Chain Monte Carlo Estimation Approach: An Application to Depression and Socio-Economic Status, Elizabeth Garrett, Richard Miech, Pamela Owens, William W. Eaton, and Scott L. Zeger

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A Nested Unsupervised Approach to Identifying Novel Molecular Subtypes, Elizabeth Garrett and Giovanni Parmigiani

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Joint Modeling and Estimation for Recurrent Event Processes and Failure Time Data, Chiung-Yu Huang and Mei-Cheng Wang

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Nonparametric Estimation of the Bivariate Recurrence Time Distribution, Chiung-Yu Huang and Mei-Cheng Wang

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Loss Function Based Ranking in Two-Stage, Hierarchical Models, Rongheng Lin, Thomas A. Louis, Susan M. Paddock, and Greg Ridgeway

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Uncertainty and the Value of Diagnostic Information With Application to Axillary Lymph Node Dissection in Breast Cancer, Giovanni Parmigiani

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Cross-Calibration of Stroke Disability Measures: Bayesian Analysis of Longitudinal Ordinal Categorical Data Using Negative Dependence, Giovanni Parmigiani, Heidi W. Ashih, Gregory P. Samsa, Pamela W. Duncan, Sue Min Lai, and David B. Matchar

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Optimization of Breast Cancer Screening Modalities, Yu Shen and Giovanni Parmigiani

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Stochastic Models Based on Molecular Hybridization Theory for Short Oligonucleotide Microarrays, Zhijin Wu, Richard LeBlanc, and Rafael A. Irizarry

Papers from 2002

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Estimating the Number of Essential Genes in a Genome by Random Transposon Mutagenesis, Natalie J. Blades and Karl W. Broman