We develop methods to perform model selection and parameter estimation in loglinear models for the analysis of sparse contingency tables to study the interaction of two or more factors. Typically, datasets arising from so-called full-length cDNA libraries, in the context of alternatively spliced genes, lead to such sparse contingency tables. Maximum Likelihood estimation of log-linear model coefficients fails to work because of zero cell entries. Therefore new methods are required to estimate the coefficients and to perform model selection. Our suggestions include computationally efficient penalization (Lasso-type) approaches as well as Bayesian methods using MCMC. We compare these procedures in a simulation study and we apply the proposed methods to full-length cDNA libraries, yielding valuable insight into the biological process of alternative splicing.
Bioinformatics | Computational Biology
Dahinden, Corinne; Parmigiani, Giovanni; Emerick, Mark C.; and Buhlmann, Peter, "PENALIZED LIKELIHOOD AND BAYESIAN METHODS FOR SPARSE CONTINGENCY TABLES: AN ANALYSIS OF ALTERNATIVE SPLICING IN FULL-LENGTH cDNA LIBRARIES" (November 2006). Johns Hopkins University, Dept. of Biostatistics Working Papers. Working Paper 123.