The Continual Reassessment Method (CRM) has gained popularity since its proposal by O’Quigley et al. . Many variations have been published and discussed in the statistical literature, but there has been little attention to making the design considerations accessible to non-statisticians. As a result, some clinicians or reviewers of clinical trials tend to be wary of the CRM due to safety concerns. This paper presents the CRM in a non-technical way, describing the original CRM with some of its modified versions. It also describes the specifications that define a CRM design, along with two simulated examples of CRMs for illustration.
Garrett-Mayer, Elizabeth, "Understanding the Continual Reassessment Method for Dose Finding Studies: An Overview for Non-Statisticians" (March 2005). Johns Hopkins University, Dept. of Biostatistics Working Papers. Working Paper 74.