This report examines in detail a family of efficacy-toxicity trade-off functions simpler and more general than those originally proposed in . The new trade-off functions are based on distance in Lp norm to the ideal point and were first presented in . We define and illustrate these functions and demonstrate how to compute their parameters based on elicited values.
Statistical Methodology | Statistical Theory
Cook, John D., "Efficacy-Toxicity trade-offs based on Lp norms" (December 2006). UT MD Anderson Cancer Center Department of Biostatistics Working Paper Series. Working Paper 29.