Adaptively randomized trials aim to treat patients in clinical trials more effectively by increasing the probability of assigning treatments that appear to have a higher probability of response. Studies of adaptive randomization to date have assumed constant probabilities of response on each treatment. This paper examines the effect of response probabilities that change over time due to population drift.
Statistical Methodology | Statistical Theory
Cook, John D., "The Effect of Population Drift on Adaptively Randomized Trials" (December 2007). UT MD Anderson Cancer Center Department of Biostatistics Working Paper Series. Working Paper 39.