The Division of Biostatistics is one of five divisions of the School of Public Health at the University of California, Berkeley. Its mission is the promotion of teaching and research of biostatistical methods by faculty and graduate students. Graduate students are admitted to M.A. and Ph.D. programs through the Group in Biostatistics which is a joint program of the School of Public Health and the Department of Statistics.

The Biostatistics Working Paper series includes articles on statistical methods and applications developed by faculty and visitors of the Division of Biostatistics. In general, articles dated 2001 and later are downloadable from this site. For earlier articles that have appeared in print, we have included an abstract with a citation. Articles that are not downloadable or are unavailable in print may be requested from

Nicholas P. Jewell
Chair, Group in Biostatistics
University of California, Berkeley
140 Warren Hall
Berkeley, CA 94720-7360

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Papers from 2003

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Resampling-based Multiple Testing: Asymptotic Control of Type I Error and Applications to Gene Expression Data, Katherine S. Pollard and Mark J. van der Laan

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Unified Cross-Validation Methodology For Selection Among Estimators and a General Cross-Validated Adaptive Epsilon-Net Estimator: Finite Sample Oracle Inequalities and Examples, Mark J. van der Laan and Sandrine Dudoit

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Asymptotic Optimality of Likelihood Based Cross-Validation, Mark J. van der Laan, Sandrine Dudoit, and Sunduz Keles

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Multiple Testing. Part II. Step-Down Procedures for Control of the Family-Wise Error Rate, Mark J. van der Laan, Sandrine Dudoit, and Katherine S. Pollard

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Double Robust Estimation in Longitudinal Marginal Structural Models, Zhuo Yu and Mark J. van der Laan

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Measuring Treatment Effects Using Semiparametric Models, Zhuo Yu and Mark J. van der Laan

Papers from 2002

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Locally Efficient Estimation of Regression Parameters Using Current Status Data, Chris Andrews, Mark J. van der Laan, and James M. Robins

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Analysis of Longitudinal Marginal Structural Models , Jennifer F. Bryan, Zhuo Yu, and Mark J. van der Laan

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Accelerated Hazards Model: Method, Theory and Applications, Ying Qing Chen, Nicholas P. Jewell, and Jingrong Yang

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Regression Analysis of Recurrent Gap Times with Time-Dependent Covariates, Ying Qing Chen, Mei-Cheng Wang, and Yijian Huang

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Semiparametric Regression Analysis on Longitudinal Pattern of Recurrent Gap Times, Ying Qing Chen, Mei-Cheng Wang, and Yijian Huang

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Inference for Proportional Mean Residual Life Model in the Presence of Censoring, Ying Q. Chen and Nicholas P. Jewell

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Multiple Hypothesis Testing in Microarray Experiments, Sandrine Dudoit, Juliet Popper Shaffer, and Jennifer C. Boldrick

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An Empirical Study of Marginal Structural Models for Time-Independent Treatment, Tanya A. Henneman and Mark J. van der Laan

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Estimating Causal Parameters in Marginal Structural Models with Unmeasured Confounders Using Instrumental Variables, Tanya A. Henneman, Mark Johannes van der Laan, and Alan E. Hubbard

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Case-Control Current Status Data, Nicholas P. Jewell and Mark J. van der Laan

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Current Status Data: Review, Recent Developments and Open Problems, Nicholas P. Jewell and Mark J. van der Laan

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Estimation of the Bivariate Survival Function with Generalized Bivariate Right Censored Data Structures, Sunduz Keles, Mark J. van der Laan, and James M. Robins

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Recurrent Events Analysis in the Presence of Time Dependent Covariates and Dependent Censoring, Maja Miloslavsky, Sunduz Keles, Mark J. van der Laan, and Steve Butler

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Comparative Genomic Hybridization Array Analysis, Annette M. Molinaro, Mark J. van der Laan, and Dan H. Moore

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Why Prefer Double Robust Estimates? Illustration with Causal Point Treatment Studies, Romain Neugebauer and Mark J. van der Laan

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A Method to Identify Significant Clusters in Gene Expression Data, Katherine S. Pollard and Mark J. van der Laan

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Locally Efficient Estimation with Bivariate Right Censored Data , Christopher M. Quale, Mark J. van der Laan, and James M. Robins

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Bivariate Current Status Data, Mark J. van der Laan and Nicholas P. Jewell

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A New Partitioning Around Medoids Algorithm, Mark J. van der Laan, Katherine S. Pollard, and Jennifer Bryan

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Construction of Counterfactuals and the G-computation Formula, Zhuo Yu and Mark J. van der Laan

Papers from 2001

Paired and Unpaired Comparisons and Clustering with Gene Expression Data, Jennifer F. Bryan, Katherine S. Pollard, and Mark J. van der Laan

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Mixture Hazards Models with Additive Random Effects Accounting for Treatment Effectiveness Lag Time, Ying Qing Chen, C. A. Rohde, and M.-C. Wang

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Detection of Progressive Deterioration in Early Onset Schizophrenia with a New Statistical Method, Ying Qing Chen, Mei-Cheng Wang, and William W. Eaton

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Marginal Regression of Gaps Between Recurrent Events, Yijian Huang and Ying Qing Chen

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Maximum Likelihood Estimation of Ordered Multinomial Parameters, Nicholas P. Jewell and John D. Kalbfleisch

Nonparametric Estimation from Current Status Data with Competing Risks, Nicholas P. Jewell, Mark J. van der Laan, and Tanya Henneman

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Identification of Regulatory Elements Using A Feature Selection Method, Sunduz Keles, Mark J. van der Laan, and Michael B. Eisen

Fitting of Mixtures with Unspecified Number of Components Using Cross Validation Distance Estimate, Maja Miloslavsky and Mark J. van der Laan

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Statistical Inference for Simultaneous Clustering of Gene Expression Data, Katherine S. Pollard and Mark J. van der Laan

Smooth Hazard Function Estimation for Interval Censored Data with Time Varying Covariates, Christopher Quale and Peter Bacchetti

Locally Efficient Estimation with Bivariate Right Censored Data, Christopher M. Quale, Mark J. van der Laan, and James M. Robins

Current Status and Right-Censored Data Structures When Observing a Marker at the Censoring Time, Mark J. van der Laan and Nicholas P. Jewell

Hybrid Clustering of Gene Expression Data with Visualization and the Bootstrap, Mark J. van der Laan and Katherine S. Pollard

Smooth Estimation of a Monotone Density, Aad W. van der Vaart and Mark J. van der Laan

Papers from 2000

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A Class of Semiparametric Scale-Change Hazards Regression Models and Its Adequacy for Censored Survival Data, Ying Qing Chen

On a General Class of Semiparametric Hazards Regression Models, Ying Qing Chen and Nicholas P. Jewell

Gene Expression Analysis with the Parametric Bootstrap, Mark J. van der Laan and Jennifer F. Bryan

Locally Efficient Estimation in Censored Data Models: Theory and Examples, Mark J. van der Laan, Richard D. Gill, and James M. Robins

Locally Efficient Estimation of a Multivariate Survival Function in Longitudinal Studies, Mark J. van der Laan, Alan E. Hubbard, and James M. Robins

Papers from 1999

Assessing Adequacy of the Semiparametric Scale Change Hazards Regression Models, Ying Qing Chen

Analysis of Accelerated Hazards Models, Ying Qing Chen and Mei-Cheng Wang

Estimating a Treatment Effect by the Accelerated Hazards Model, Ying Qing Chen and Mei-Cheng Wang

The NPMLE in the Uniform Doubly Censored Current Status Data Model, Mark J. van der Laan and Nicholas P. Jewell

Papers from 1998

Automating Data Entry and Validation in Clinical Research, Andrew D. Graham, Robert E. Fusaro, and Kenneth A. Polse

Nonparametric Locally Efficient Estimation of the Treatment Specific Survival Distribution with Right Censored Data and Covariates in Observational Studies, Alan E. Hubbard, Mark J. van der Laan, and James M. Robins

Subset Selection in Explanatory Regression Analyses, Derick R. Peterson and Richard J. Brand

Inference with Bivariate Truncated Data, Christopher M. Quale and Mark J. van der Laan

Estimation with Interval Censored Data in Longitudinal Studies, Mark J. van der Laan

The Nonparametric Maximum Likelihood Estimator in a Class of Doubly Censored Current Status Data Models with Application to Partner Studies, Mark J. van der Laan and Chris Andrews

Locally Efficient Estimation of the Quality Adjusted Lifetime Distribution with Right-Censored Data and Covariates, Mark J. van der Laan and Alan E. Hubbard

Nonparametric Efficient Estimation with Current Status Data and Right-Censored Data Structures When Observing a Marker at the Censoring Time, Mark J. van der Laan and Nicholas P. Jewell

Subset Selection Based on Order Statistics from Logistic Populations, Mark J. van der Laan and Paul van der Laan

Papers from 1997

Locally Efficient Estimation of the Survival Distribution with Right Censored Data and Covariates When Collection of Data is Delayed, Mark J. van der Laan and Alan E. Hubbard

Efficient Estimation of the Lifetime and Disease Onset Distribution, Mark J. van der Laan, Nicholas P. Jewell, and Derick R. Peterson

Efficient Estimation from Right-Censored Data When Failure Indicators are Missing at Random, Mark J. van der Laan and Ian W. McKeague

Smooth Estimation and Inference with Interval Censored Data, Mark J. van der Laan and Derick R. Peterson

Locally Efficient Estimation with Current Status Data and Time-Dependent Covariates, Mark J. van der Laan and James M. Robins

Papers from 1996

Backcalculation of Multiple Sclerosis Incidence Rates Based on Faroe Islands Data, Nicholas P. Jewell and Biao Wm. Lu

Singly and Doubly Censored Current Status Data With Extensions to Multi-State Counting Processes, Nicholas P. Jewell and Mark J. van der Laan

Estimation with Interval Censored Data and Covariates, Mark J. van der Laan and Alan E. Hubbard

Papers from 1995

A Modification of the Re-Distribution to the Right Algorithm Using Disease Markers, Hina M. Malani

Efficiency of the Sieved-NPMLE in CAR-Missing Data Models, Mark J. van der Laan

Locally Efficient Estimation with Current Status Data and High Dimensional Covariates, Mark J. van der Laan

Nonparametric Estimation of the Bivariate Survival Function with Truncated Data, Mark J. van der Laan

The Two-Interval Line-Segment Problem, Mark J. van der Laan

Papers from 1994

Double Censoring and All That: Problems in Biostatistical Inference, Nicholas P. Jewell

Generalizations of Current Status Data With Applications, Nicholas P. Jewell and Mark J. van der Laan

Simulation Properties of Malani's Modified Kaplan-Meier Estimator, Sandra R. Percell and Hina M. Malani

Regression with Doubly Censored Current Status Data, Daniel Rabinowitz and Nicholas P. Jewell

Efficient and Ad Hoc Estimation in the Bivariate Censoring Model, Mark J. van der Laan

Proving Efficiency of NPMLE and Identities, Mark J. van der Laan

Singly and Doubly Censored Current Status Data: Estimation, Asymptotics and Regression, Mark J. van der Laan, Peter J. Bickel, and Nicholas P. Jewell

Semi-Parametric Estimation of the Mean Trajectory of a Marker Using Data from a Prevalent Cohort, Eric Vittinghoff, Hina M. Malani, and Nicholas P. Jewell

Papers from 1993

A Competing Risks Analysis of Presenting AIDS Diagnoses Trends, Robert E. Fusaro, Peter Bacchetti, and Nicholas P. Jewell

A Markov Chain Monte Carlo Approach to the Nonlinear Mixed Model for Repeated Measures Data, Jack Gerson, Richard J. Brand, and Jonathan Raz

Non-Parametric Estimation and Doubly-Censored Data: General Ideas and Applications to AIDS, Nicholas P. Jewell

Shaping the Future of Public Health: The Role of Biostatistics, Nicholas P. Jewell

Papers from 1992

Uncertainty About the Incubation Period of AIDS and its Impact on Backcalculation, Peter R. Bacchetti, Mark R. Segal, and Nicholas P. Jewell

Backcalculation of HIV Infection Rates, Peter Bacchetti, Mark R. Segal, and Nicholas P. Jewell

Generation of Simplex Lattice Points, Scott Chasalow and Richard Brand

Markers Models in Survival Analysis and Applications to Issues Associated with AIDS, Nicholas P. Jewell and John D. Kalbfleisch

Nonparametric Estimation for a Form of Doubly Censored Data, with Application to Two Problems in AIDS, Nicholas P. Jewell, Hina M. Malani, and Eric Vittinghoff

Estimating Multiple Tumor Transition Rates Based on Data from Survival/Sacrifice Experiments, Ying Lu and Hina M. Malani

A Note on the Asymptotic Variance of Survival Function in the Semi-Markov Model, Hina M. Malani, Jens Nielsen, and William J. Redfearn

Variances for Maximum Penalized Likelihood Estimates Obtained via the EM Algorithm, Mark R. Segal, Peter Bacchetti, and Nicholas P. Jewell

Estimating Patterns of CD4+ Lymphocyte Decline Using Data from a Prevalent Cohort of HIV Infected Individuals, Eric Vittinghoff, Hina M. Malani, and Nicholas P. Jewell

Papers from 1991

An Annotated Bibliography of Methods for Analyzing Correlated Categorical Data, Mark Ashby, John M. Neuhaus, Walter W. Hauck, Peter Bacchetti, David C. Heilbron, Nicholas P. Jewell, Mark R. Segal, and Robert E. Fusaro

The Impact of Uncertainty in the AIDS Incubation Period on Reconstructions of the HIV Epidemic, Peter Bacchetti, Mark R. Segal, and Nicholas P. Jewell

Marker-Dependent Hazard Estimation: An Application to AIDS, Robert E. Fusaro, Jens P. Nielsen, and Thomas H. Scheike

Comparing the Positive Jackknife with the Usual Jackknife, Nicholas P. Jewell

Marker Processes in Survival Analysis, Nicholas P. Jewell and John D. Kalbfleisch

The Design and Analysis of Partner Studies of HIV Transmission, Nicholas P. Jewell and Stephen C. Shiboski

A Geometric Approach to Assess Bias Due to Omitted Covariates in Generalized Linear Models, John M. Neuhaus and Nicholas P. Jewell

A Framework for Consistent Prediction Rules Based on Markers, Jens Perch Nielsen and Nicholas P. Jewell