The Division of Biostatistics is one of five divisions of the School of Public Health at the University of California, Berkeley. Its mission is the promotion of teaching and research of biostatistical methods by faculty and graduate students. Graduate students are admitted to M.A. and Ph.D. programs through the Group in Biostatistics which is a joint program of the School of Public Health and the Department of Statistics.

The Biostatistics Working Paper series includes articles on statistical methods and applications developed by faculty and visitors of the Division of Biostatistics. In general, articles dated 2001 and later are downloadable from this site. For earlier articles that have appeared in print, we have included an abstract with a citation. Articles that are not downloadable or are unavailable in print may be requested from

Nicholas P. Jewell
Chair, Group in Biostatistics
University of California, Berkeley
140 Warren Hall
Berkeley, CA 94720-7360

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Papers from 1994

Simulation Properties of Malani's Modified Kaplan-Meier Estimator, Sandra R. Percell and Hina M. Malani

Regression with Doubly Censored Current Status Data, Daniel Rabinowitz and Nicholas P. Jewell

Efficient and Ad Hoc Estimation in the Bivariate Censoring Model, Mark J. van der Laan

Proving Efficiency of NPMLE and Identities, Mark J. van der Laan

Singly and Doubly Censored Current Status Data: Estimation, Asymptotics and Regression, Mark J. van der Laan, Peter J. Bickel, and Nicholas P. Jewell

Semi-Parametric Estimation of the Mean Trajectory of a Marker Using Data from a Prevalent Cohort, Eric Vittinghoff, Hina M. Malani, and Nicholas P. Jewell

Papers from 1993

A Competing Risks Analysis of Presenting AIDS Diagnoses Trends, Robert E. Fusaro, Peter Bacchetti, and Nicholas P. Jewell

A Markov Chain Monte Carlo Approach to the Nonlinear Mixed Model for Repeated Measures Data, Jack Gerson, Richard J. Brand, and Jonathan Raz

Non-Parametric Estimation and Doubly-Censored Data: General Ideas and Applications to AIDS, Nicholas P. Jewell

Shaping the Future of Public Health: The Role of Biostatistics, Nicholas P. Jewell

Papers from 1992

Uncertainty About the Incubation Period of AIDS and its Impact on Backcalculation, Peter R. Bacchetti, Mark R. Segal, and Nicholas P. Jewell

Backcalculation of HIV Infection Rates, Peter Bacchetti, Mark R. Segal, and Nicholas P. Jewell

Generation of Simplex Lattice Points, Scott Chasalow and Richard Brand

Markers Models in Survival Analysis and Applications to Issues Associated with AIDS, Nicholas P. Jewell and John D. Kalbfleisch

Nonparametric Estimation for a Form of Doubly Censored Data, with Application to Two Problems in AIDS, Nicholas P. Jewell, Hina M. Malani, and Eric Vittinghoff

Estimating Multiple Tumor Transition Rates Based on Data from Survival/Sacrifice Experiments, Ying Lu and Hina M. Malani

A Note on the Asymptotic Variance of Survival Function in the Semi-Markov Model, Hina M. Malani, Jens Nielsen, and William J. Redfearn

Variances for Maximum Penalized Likelihood Estimates Obtained via the EM Algorithm, Mark R. Segal, Peter Bacchetti, and Nicholas P. Jewell

Estimating Patterns of CD4+ Lymphocyte Decline Using Data from a Prevalent Cohort of HIV Infected Individuals, Eric Vittinghoff, Hina M. Malani, and Nicholas P. Jewell

Papers from 1991

An Annotated Bibliography of Methods for Analyzing Correlated Categorical Data, Mark Ashby, John M. Neuhaus, Walter W. Hauck, Peter Bacchetti, David C. Heilbron, Nicholas P. Jewell, Mark R. Segal, and Robert E. Fusaro

The Impact of Uncertainty in the AIDS Incubation Period on Reconstructions of the HIV Epidemic, Peter Bacchetti, Mark R. Segal, and Nicholas P. Jewell

Marker-Dependent Hazard Estimation: An Application to AIDS, Robert E. Fusaro, Jens P. Nielsen, and Thomas H. Scheike

Comparing the Positive Jackknife with the Usual Jackknife, Nicholas P. Jewell

Marker Processes in Survival Analysis, Nicholas P. Jewell and John D. Kalbfleisch

The Design and Analysis of Partner Studies of HIV Transmission, Nicholas P. Jewell and Stephen C. Shiboski

A Geometric Approach to Assess Bias Due to Omitted Covariates in Generalized Linear Models, John M. Neuhaus and Nicholas P. Jewell

A Framework for Consistent Prediction Rules Based on Markers, Jens Perch Nielsen and Nicholas P. Jewell

Distance and Risk Measures for the Analysis of Spatial Data: A Study of Childhood Cancers, Steve Selvin, Jane Schulman, and Deane W. Merrill

Papers from 1990

Nonparametric Estimation of the Incubation Period of AIDS Based on a Prevalent Cohort with Unknown Infection Times, Peter Bacchetti and Nicholas P. Jewell

Analysis of Animal Carcinogenicity Experiments with Multiple Tumor Types, Ying Lu and Hina M. Malani

Examination of Effects of Lethality and Mortality Rates on the Tests of Carcinogenicity Using the ED01 Study, Hina M. Malani and Ying Lu

Fractional Moments and the Modified Weyl Derivative, William J. Redfearn

On the Weyl Derivative of Positive Order, William J. Redfearn

Some Surprising Results About Covariate Adjustment in Logistic Regression Models, Laurence D. Robinson and Nicholas P. Jewell

Statistical Analysis of the Time Dependence of HIV Infectivity Based on Partner Study Data, Stephen C. Shiboski and Nicholas P. Jewell

Prevalent Cohort Models in Clinical Treatment Studies: An Analysis of Zidovudine Treatment Data, Mei-Cheng Wang, Ron Brookmeyer, and Nicholas P. Jewell

Papers from 1989

Estimating the Incubation Period of AIDS by Comparing Population Infection and Diagnosis Patterns, Peter Bacchetti

An Annotated Bibliography of Quantitative Methodology Relating to the AIDS Epidemic, Robert E. Fusaro, Nicholas P. Jewell, Walter W. Hauck, David C. Heilbron, John D. Kalbfleisch, John M. Neuhaus, and Mark A. Ashby

Some Statistical Issues in Studies of the Epidemiology of AIDS, Nicholas P. Jewell

Statistical Analysis of HIV Infectivity Based on Partner Studies, Nicholas P. Jewell and Stephen C. Shiboski

Estimation of Transition Probabilities in Animal Carcinogenicity Experiments, Hina M. Malani and John Van Ryzin

Some Comments on Rosner's Multiple Logistic Model for Clustered Data, John M. Neuhaus and Nicholas P. Jewell

The Effect of Retrospective Sampling on Binary Regression Models for Clustered Data, John M. Neuhaus and Nicholas P. Jewell

Random Genetic Mosaics I. Models and Moments, William J. Redfearn

Simpson's Paradox: A Graphical Treatment, William J. Redfearn

Hypothesis Testing of Regression Parameters in Semi-Parametric Generalized Linear Models for Cluster Correlated Data, Andrea Rotnitzky and Nicholas P. Jewell