Title
Recurrent Events Analysis in the Presence of Time Dependent Covariates and Dependent Censoring
Abstract
Recurrent events models have lately received a lot of attention in the literature. The majority of approaches discussed show the consistency of parameter estimates under the assumption that censoring is independent of the recurrent events process of interest conditional on the covariates included into the model. We provide an overview of available recurrent events analysis methods, and present an inverse probability of censoring weighted estimator for the regression parameters in the Andersen-Gill model that is commonly used for recurrent event analysis. This estimator remains consistent under informative censoring if the censoring mechanism is estimated consistently, and generally improves on the naive estimator for the Anderson-Gill model in the case of independent censoring. We illustrate the bias of ad hoc estimators in the presence of informative censoring with a simulation study and provide a data analysis of recurrent lung exacerbations in cystic fibrosis patients when some patients are lost to follow up.
Disciplines
Statistical Methodology | Statistical Models | Statistical Theory | Survival Analysis
Suggested Citation
Miloslavsky, Maja; Keles, Sunduz; van der Laan, Mark J.; and Butler, Steve, "Recurrent Events Analysis in the Presence of Time Dependent Covariates and Dependent Censoring" (December 2002). U.C. Berkeley Division of Biostatistics Working Paper Series. Working Paper 123.
https://biostats.bepress.com/ucbbiostat/paper123
Included in
Statistical Methodology Commons, Statistical Models Commons, Statistical Theory Commons, Survival Analysis Commons
Comments
Published 2003 in Journal of the Royal Statistical Society, Series B, 66, Part 1, pp. 239-257.