. It is of recent interest in reproductive health research to investigate the validity of a marker event for the onset of menopausal transition and to estimate age at menopause using age at the marker event. We propose a varying coefficient Cox model to investigate the association between age at a marker event, denned as a specific bleeding pattern change, and age at menopause, where both events are subject to censoring and their association varies with age at the marker event. Estimation proceeds using the regression spline method. The proposed method is applied to the Tremin Trust Data to evaluate the association between age at onset of the 60-day menstrual cycle and age at menopause. The performance of the proposed method is evaluated using a simulation study.


Longitudinal Data Analysis and Time Series | Medical Specialties | Statistical Models | Survival Analysis