Abstract
We describe a new class of dose finding methods to be used in early phase clinical trials. Under some added parametric conditions the class reduces to the family of continual reassessment method (CRM) designs. Under some relaxation of the underlying structure the method is equivalent to the CCD, mTPI or BOIN classes of designs. These latter designs are non-parametric in nature whereas the CRM class can be viewed as being strongly parametric. The proposed class is characterized as being semi-parametric since it corresponds to CRM with a nuisance parameter. Performance is good, matching that of the CRM class and improving on it in some cases. The structure allows theoretical questions to be more easily investigated and to better understand how different classes of methods relate to one another.
Disciplines
Biostatistics
Suggested Citation
Clertant, Matthieu and O'Quigley, John, "Semi-Parametrics Dose Finding Methods" (January 2016). COBRA Preprint Series. Working Paper 116.
https://biostats.bepress.com/cobra/art116