#### Abstract

Suppose one observes a sample of independent and identically distributed observations from a particular data generating distribution. Suppose that one has available an estimate of the density of the data generating distribution such as a maximum likelihood estimator according to a given or data adaptively selected model. Suppose that one is concerned with estimation of a particular pathwise differentiable Euclidean parameter. A substitution estimator evaluating the parameter of the density estimator is typically too biased and might not even converge at the parametric rate: that is, the density estimator was targeted to be a good estimator of the density and might therefore result in a poor estimator of a particular smooth functional of the density. In this article we propose a one step (and, by iteration, k-th step) targeted maximum likelihood density estimator which involves 1) creating a hardest parametric submodel with parameter epsilon through the given density estimator with score equal to the efficient influence curve of the pathwise differentiable parameter at the density estimator, 2) estimating this parameter epsilon with the maximum likelihood estimator, and 3) defining a new density estimator as the corresponding update of the original density estimator. We show that iteration of this algorithm results in a targeted maximum likelihood density estimator which solves the efficient influence curve estimating equation and thereby yields an efficient or locally efficient estimator of the parameter of interest under regularity conditions. We also show that, if the parameter is linear and the model is convex, then the targeted maximum likelihood estimator is often achieved in the first step, and it results in a locally efficient estimator at an arbitrary (e.g., heavily misspecified) starting density. This tool provides us with a new class of targeted likelihood based estimators of pathwise differentiable parameters.

We also show that the targeted maximum likelihood estimators are now in full agreement with the locally efficient estimating function methodology as presented in Robins and Rotnitzky (1992) and van der Laan and Robins (2003), creating, in particular, algebraic equivalence between the double robust locally efficient estimators using the targeted maximum likelihood estimators as an estimate of its nuisance parameters, and targeted maximum likelihood estimators. In addition, it is argued that the targeted MLE has various advantages relative to the current estimating function based approach.We proceed by providing data driven methodologies to select the initial density estimator for the targeted MLE, thereby providing data adaptive targeted maximum likelihood estimation methodology. Finally, we show that targeted maximum likelihood estimation can be generalized to estimate any kind of parameter, such as infinite dimensional non-pathwise differentiable parameters, by restricting the likelihood and cross-validated log-likelihood to targeted candidate density estimators only. We illustrate the method with various worked out examples.

#### Disciplines

Statistical Methodology | Statistical Theory

#### Suggested Citation

van der Laan, Mark J. and Rubin, Daniel, "Targeted Maximum Likelihood Learning" (October 2006). *U.C. Berkeley Division of Biostatistics Working Paper Series.* Working Paper 213.

https://biostats.bepress.com/ucbbiostat/paper213