We present a brief overview of targeted maximum likelihood for estimating the causal effect of a single time point treatment and of a two time point treatment. We focus on simple examples demonstrating how to apply the methodology developed in (van der Laan and Rubin, 2006; Moore and van der Laan, 2007; van der Laan, 2010a,b). We include R code for the single time point case.
Statistical Methodology | Statistical Theory
Rosenblum, Michael and van der Laan, Mark J., "Simple Examples of Estimating Causal Effects Using Targeted Maximum Likelihood Estimation" (March 2010). U.C. Berkeley Division of Biostatistics Working Paper Series. Working Paper 262.