Understanding regulatory mechanisms in complex biological systems is an important challenge, in particular to understand disease mechanisms, and to discover new therapies and drugs. In this paper, we consider the important question of cellular regulation of phenotype. Using single gene deletion data, we address the problem of linking a phenotype to underlying functional roles in the organism and provide a sound computational and statistical paradigm that can be extended to address more complex experimental settings such as multiple deletions. We apply the proposed approaches to publicly available data sets to demonstrate strong evidence for the involvement of multi-protein complexes in the phenotypes studied.
Bioinformatics | Computational Biology
Le Meur, Nolwenn and Gentleman, Robert, "Assessing The Role Of Multi-protein Complexes In Determining Phenotype" (January 2008). Bioconductor Project Working Papers. Working Paper 13.