For a continuous-scale test, it is an interest to construct a confidence interval for the sensitivity of the diagnostic test at the cut-off that yields a predetermined level of its specificity (eg. 80%, 90%, or 95%). IN this paper we proposed two new intervals for the sensitivity of a continuous-scale diagnostic test at a fixed level of specificity. We then conducted simulation studies to compare the relative performance of these two intervals with the best existing BCa bootstrap interval, proposed by Platt et al. (2000). Our simulation results showed that the newly proposed intervals are better than the BCa bootstrap interval in terms of coverage accuracy and interval length.
Categorical Data Analysis | Epidemiology | Statistical Methodology | Statistical Theory
Zhou, Xiao-Hua and Qin, Gengsheng, "Improved Confidence Intervals for the Sensitivity at a Fixed Level of Specificity of a Continuous-Scale Diagnostic Test" (May 2003). UW Biostatistics Working Paper Series. Working Paper 203.