The COBRA Preprint Series contains manuscripts by top researchers, many of which will eventually appear in leading journals. For a look ahead to tomorrow's cutting edge research, browse the papers below.
Submissions from 2024
Assessing the Adequacy of a Prediction Model, Abhaya Indrayan and Sakshi Mishra Ms
An improved Bayesian pick-the-winner (IBPW) design for randomized phase II clinical trials, Wanni Lei, Maosen Peng, and Xi K. Zhou
Submissions from 2022
A simple and robust alternative to Bland-Altman method of assessing clinical agreement, Abhaya Indrayan Prof
Submissions from 2019
Supervised Dimension Reduction for Large-scale "Omics" Data with Censored Survival Outcomes Under Possible Non-proportional Hazards, Lauren Spirko-Burns and Karthik Devarajan
Unified Methods for Feature Selection in Large-Scale Genomic Studies with Censored Survival Outcomes, Lauren Spirko-Burns and Karthik Devarajan
Submissions from 2018
A SPLINE-ASSISTED SEMIPARAMETRIC APPROACH TO NONPARAMETRIC MEASUREMENT ERROR MODELS, Fei Jiang and Yanyuan Ma
Submissions from 2016
Semi-Parametrics Dose Finding Methods, Matthieu Clertant and John O'Quigley
hpcNMF: A high-performance toolbox for non-negative matrix factorization, Karthik Devarajan and Guoli Wang
Submissions from 2015
STATISTICAL HANDLING OF MEDICAL DATA - AN ETHICAL PERSPECTIVE, Ajay Kumar Bansal Dr
Distance Correlation Measures Applied to Analyze Relation between Variables in Liver Cirrhosis Marker Data, Atanu Bhattacharjee Dr.
A Simple Method to Estimate the Time-dependent ROC Curve Under Right Censoring, Liang Li, Bo Hu, and Tom Greene
Submissions from 2014
Bayesian Model Averaging:- An Application in Cancer Clinical Trial, Atanu Bhattacharjee
Pre-maceration, Saignée and Temperature affect Daily Evolution of Pigment Extraction During Vinification, Ottorino L. Pantani, Federico M. Stefanini, Irene Lozzi, Luca Calamai, Alessandra Biondi Bartolini, and Stefano Di Blasi
Computational model for survey and trend analysis of patients with endometriosis : a decision aid tool for EBM, Salvo Reina, Vito Reina, Franco Ameglio, Mauro Costa, and Alessandro Fasciani
Methods for Exploring Treatment Effect Heterogeneity in Subgroup Analysis: An Application to Global Clinical Trials, I. Manjula Schou and Ian C. Marschner
Variable selection for zero-inflated and overdispersed data with application to health care demand in Germany, Zhu Wang, Shuangge Ma, and Ching-Yun Wang
Submissions from 2013
Augmentation of Propensity Scores for Medical Records-based Research, Mikel Aickin
Regression Trees for Longitudinal Data, Madan Gopal Kundu and Jaroslaw Harezlak
A Bayesian regression tree approach to identify the effect of nanoparticles properties on toxicity profiles, Cecile Low-Kam, Haiyuan Zhang, Zhaoxia Ji, Tian Xia, Jeffrey I. Zinc, Andre Nel, and Donatello Telesca
Submissions from 2012
Estimating HIV prevalence in the presence of spatial variation, Matthew D. Austin, Christopher D. Barr, and Victor DeGruttola
A prior-free framework of coherent inference and its derivation of simple shrinkage estimators, David R. Bickel
Relating Nanoparticle Properties to Biological Outcomes in Exposure Escalation Experiments, Trina Patel, Cecile Low-Kam, Zhaoxia Ji, Haiyuan Zhang, Tian Xia, Andre E. Nel, Jeffrey I. Zinc, and Donatello Telesca
Hierarchical Rank Aggregation with Applications to Nanotoxicology, Trina Patel, Donatello Telesca, Robert Rallo, Saji George, Xia Tian, and Nel Andre
Quantifying alternative splicing from paired-end RNA-sequencing data, David Rossell, Camille Stephan-Otto Attolini, Manuel Kroiss, and Almond Stöcker
Robust Estimation of Pure/Natural Direct Effects with Mediator Measurement Error, Eric J. Tchetgen Tchetgen and Sheng Hsuan Lin
On Identification of Natural Direct Effects when a Confounder of the Mediator is Directly Affected by Exposure, Eric J. Tchetgen Tchetgen and Tyler J. VanderWeele
Robustness of Measures of Interaction to Unmeasured Confounding, Eric J. Tchetgen Tchetgen and Tyler J. VanderWeele
Differential Patterns of Interaction and Gaussian Graphical Models, Masanao Yajima, Donatello Telesca, Yuan Ji, and Peter Muller
PLS-ROG: Partial least squares with rank order of groups, Hiroyuki Yamamoto
Statistical hypothesis test of factor loading in principal component analysis and its application to metabolite set enrichment analysis, Hiroyuki Yamamoto, Tamaki Fujimori, Hajime Sato, Gen Ishikawa, Kenjiro Kami, and Yoshiaki Ohashi
Why odds ratio estimates of GWAS are almost always close to 1.0, Yutaka Yasui
Submissions from 2011
A unified approach to non-negative matrix factorization and probabilistic latent semantic indexing, Karthik Devarajan, Guoli Wang, and Nader Ebrahimi
Evaluation of Flexible Regression for Non-unimodal Hazard Functions, Marco Fornili, Patrizia Boracchi, Federico Ambrogi, and Elia Biganzoli
Propensity Score Analysis with Matching Weights, Liang Li
On the Nondifferential Misclassification of a Binary Confounder, Elizabeth L. Ogburn and Tyler J. VanderWeele
Toxicity Profiling of Engineered Nanomaterials via Multivariate Dose Response Surface Modeling, Trina Patel, Donatello Telesca, Saji George, and Andre Nel
A proof of Bell's inequality in quantum mechanics using causal interactions, James M. Robins, Tyler J. VanderWeele, and Richard D. Gill
Modeling Criminal Careers as Departures from a Unimodal Population Age-Crime Curve: The Case of Marijuana Use, Donatello Telesca, Elena Erosheva, Derek Kreager, and Ross Matsueda
Modeling Protein Expression and Protein Signaling Pathways, Donatello Telesca, Peter Muller, Steven Kornblau, Marc Suchard, and Yuan Ji
Causal inference under multiple versions of treatment, Tyler J. VanderWeele and Miguel A. Hernan
On the definition of a confounder, Tyler J. VanderWeele and Ilya Shpitser
Components of the indirect effect in vaccine trials: identification of contagion and infectiousness effects, Tyler J. VanderWeele, Eric J. Tchetgen, and M. Elizabeth Halloran
A Bayesian Model Averaging Approach for Observational Gene Expression Studies, Xi Kathy Zhou, Fei Liu, and Andrew J. Dannenberg
Submissions from 2010
A Bayesian shared component model for genetic association studies, Juan J. Abellan, Carlos Abellan, and Juan R. Gonzalez
Recovery of the Baseline Incidence Density in Censored Time-to-Event Analysis, Mikel Aickin
The Linkset Model for 2^n Contingency Tables, Mikel Aickin
The Strength of Statistical Evidence for Composite Hypotheses: Inference to the Best Explanation, David R. Bickel
Efficient Design and Inference for Multi-stage Randomized Trials of Individualized Treatment Policies, Ree Dawson and Philip W. Lavori
The use of multiple imputation in molecular epidemiologic studies assessing interaction effects, Manisha Desai, Denise Esserman, Marilie Gammon, and Mary Beth Terry
The handling of missing data in molecular epidemiologic studies, Manisha Desai, Jessica Kubo, Denise Esserman, and Mary Beth Terry
Improving statistical analysis of prospective clinical trials in stem cell transplantation. An inventory of new approaches in survival analysis, Aurelien Latouche
Minimum Description Length and Empirical Bayes Methods of Identifying SNPs Associated with Disease, Ye Yang and David R. Bickel
Minimum Description Length Measures of Evidence for Enrichment, Zhenyu Yang and David R. Bickel
Submissions from 2009
Simple, Defensible Sample Sizes Based on Cost Efficiency -- With Discussion and Rejoinder, Peter Bacchetti, Charles E. McCulloch, Mark R. Segal, Richard Simon, Peter Muller, Gary L. Rosner, James A. Hanley, and Stan Shapiro
Reliability of the Model for Clustering of Longitudinal datasets of Infant Mortality Rate in India, Ajay Kumar Bansal and S D. Sharma
Validation of Differential Gene Expression Algorithms: Application Comparing Fold Change Estimation to Hypothesis Testing, David R. Bickel and Corey M. Yanofsky
Two-stage Decompositions for the Analysis of Functional Connectivity for fMRI With Application to Alzheimer's Disease Risk, Brian S. Caffo, Ciprian M. Crainiceanu, Guillermo Verduzco, Stewart H. Mostofsky, Susan Spear-Bassett, and James J. Pekar
Nonparametric Incidence Estimation From Prevalent Cohort Survival Data, Marco Carone, Masoud Asgharian, and Mei-Cheng Wang
Composite Likelihood EM Algorithm with Applications to Multivariate Hidden Markov Model , Xin Gao and Peter Xuekun Song
Fitting ACE Structural Equation Models to Case-Control Family Data, Kristin N. Javaras, James I. Hudson, and Nan M. Laird
Targeted Genomic signature profiling with Quasi-alignment statistics, Rao Mallik Kotamarti, Douglas W. Raiford, Michael Hahsler, Yuhang Wang, Monnie McGee, and Maggie Dunham
Shrinkage Estimation of Expression Fold Change As an Alternative to Testing Hypotheses of Equivalent Expression, Zahra Montazeri, Corey M. Yanofsky, and David R. Bickel
A Novel Topology for Representing Protein Folds, Mark R. Segal
Modeling Multilevel Sleep Transitional Data Via Poisson Log-Linear Multilevel Models, Bruce J. Swihart
Mean Survival Time from Right Censored Data, Ming Zhong and Kenneth R. Hess
Correlated Binary Regression Using Orthogonalized Residuals, Richard C. Zink and Bahjat F. Qaqish
Submissions from 2008
The Strength of Statistical Evidence for Composite Hypotheses with an Application to Multiple Comparisons, David R. Bickel
Reversal in declining trend of adult mortality in many states of India, 1970-2001: Is it due to AIDS?, Abhaya Indrayan and Ajay Kumar Bansal
A SIMPLE INDEX OF SMOKING, Abhaya Indrayan Dr., Rajeev Kumar Mr., and Shridhar Dwivedi Dr.
Change-point Problem and Regression: An Annotated Bibliography, Ahmad Khodadadi and Masoud Asgharian
The Calculation of the 97.5% Upper Confidence Bound: Application to Clustered Binary Data in a Binomial Non-Inferiority Two-Sample Trial., William F. McCarthy
The Design and Sample Size Requirement for a Cluster Randomized Non-Inferiority Trial with Two Binary Co-Primary Outcomes., William F. McCarthy
Joint Spatial Modeling of Recurrent Infection and Growth with Processes Under Intermittent Observation, Farouk S. Nathoo
Space-Time Regression Modeling of Tree Growth Using the Skew-t Distribution, Farouk S. Nathoo
Detection of Recurrent Copy Number Alterations in the Genome: a Probabilistic Approach, Oscar M. Rueda and Ramon Diaz-Uriarte
Finding Recurrent Regions of Copy Number Variation: A Review, Oscar M. Rueda and Ramon Diaz-Uriarte
A New Method for Constructing Exact Tests without Making any Assumptions, Karl H. Schlag
Bringing Game Theory to Hypothesis Testing: Establishing Finite Sample Bounds on Inference, Karl H. Schlag
Properties of Monotonic Effects on Directed Acyclic Graphs, Tyler J. VanderWeele and James M. Robins
Properties of Monotonic Effects on Directed Acyclic Graphs, Tyler J. VanderWeele and James M. Robins
Submissions from 2007
Improving GSEA for Analysis of Biologic Pathways for Differential Gene Expression across a Binary Phenotype , Irina Dinu, John D. Potter, Thomas Mueller, Qi Liu, Adeniyi J. Adewale, Gian S. Jhangri, Gunilla Einecke, Konrad S. Famulski, Philip Halloran, and Yutaka Yasui
Bootstrap Confidence Regions for Optimal Operating Conditions in Response Surface Methodology, Roger D. Gibb, I-Li Lu, and Walter H. Carter Jr
Estimating the Prevalence of Disease Using Relatives of Case and Control Probands, Kristin N. Javaras, Nan M. Laird, James I. Hudson, and Brian D. Ripley
Adjustment to the McNemar’s Test for the Analysis of Clustered Matched-Pair Data, William F. McCarthy
An Example of How to Write the Statistical Section of a Bioequivalence Study Protocol for FDA Review, William F. McCarthy
Assessment of Sample Size and Power for the Analysis of Clustered Matched-Pair Data, William F. McCarthy
Lachenbruch’s Method for Determining the Sample Size Required for Testing Interactions: How It Compares to nQuery Advisor and O’Brien’s SAS UnifyPow., William F. McCarthy
The Existence of Maximum Likelihood Estimates for the Binary Response Logistic Regression Model, William F. McCarthy
The Assessment of the Degree of Concordance Between the Observed Values and the Predicted Values of a Mixed-Effect Model Using “Method of Comparison” Techniques, William F. McCarthy and Nan Guo
The Analysis of Pixel Intensity (Myocardial Signal Density) Data: The Quantification of Myocardial Perfusion by Imaging Methods., William F. McCarthy and Douglas R. Thompson
Coronary Evaluation Using Multi-detector Spiral Computed Tomography Angiography: Statistical Design and Analysis, William F. McCarthy, Douglas R. Thompson, and Bruce A. Barton
Estimation of Dose-Response Functions for Longitudinal Data, Erica E M Moodie and David A. Stephens
Review of the Maximum Likelihood Functions for Right Censored Data. A New Elementary Derivation., Stefano Patti, Elia Biganzoli, and Patrizia Boracchi
False Discovery Rate Analysis of Brain Diffusion Direction Maps, Armin Schwartzman, Robert F. Dougherty, and Jonathan E. Taylor
A Bayesian hierarchical model for spot fluorescence in microarrays, Federico Mattia Stefanini
A Flexible Semi-Parametric Approach to Estimating a Dose-Response Relationship: the Treatment of Childhood Amblyopia. , David A. Stephens and Erica E M Moodie
Submissions from 2006
Crude Cumulative Incidence in the form of a Horvitz-Thompson like and Kaplan-Meier like Estimator, Laura Antolini, Elia Mario Biganzoli, and Patrizia Boracchi
Exploration of distributional models for a novel intensity-dependent normalization , Nicola Lama, Patrizia Boracchi, and Elia Mario Biganzoli
New Spiked-In Probe Sets for the Affymetrix HGU-133A Latin Square Experiment, Monnie McGee and Zhongxue Chen
Survival Analysis of Longitudinal Microarrays, Natasa Rajicic, Dianne M. Finkelstein, and David A. Schoenfeld